Which on-chain metrics like NUPL and MVRV signal major BTC trend changes?

[AnthonyS]

I've been following Bitcoin for a while, but I'm trying to move beyond just watching the price and understand the technical and on-chain metrics that more experienced traders use for their Bitcoin price analysis. I'm familiar with basic moving averages, but terms like NUPL, MVRV Z-Score, and hash ribbons are still confusing to me. For those who incorporate these deeper metrics, which ones have you found to be the most reliable leading indicators for major trend changes, and how do you weigh them against broader macro factors?