What are the main challenges retrieving hot Jupiter atmospheres with JWST data?

[Gary32]

I'm an astronomy graduate student starting my thesis research, and I've chosen to focus on modeling exoplanet atmospheres, specifically for hot Jupiters observed with transmission spectroscopy. I'm struggling with interpreting the spectral data from JWST, particularly when trying to disentangle the signatures of different molecular abundances and clouds/hazes from the noise. For researchers in this niche, what are the current biggest challenges and most promising techniques for atmospheric retrieval? How do you validate your models against the sparse data we have, and are there specific chemical regimes or planetary types where our current understanding of exoplanet atmospheres is most likely to see a breakthrough in the next few years?