Balancing trial evidence with individualized care for multimorbid patients

[AbigailB]

I'm a general practitioner, and I'm increasingly frustrated by the gap between the robust evidence from large clinical trials we learn about and the complex, multi-morbid patients I see daily in my clinic, where strict trial protocols rarely apply. It's challenging to integrate evidence-based medicine into personalized care plans, especially when patients have conflicting conditions or are on multiple medications. For other clinicians, how do you practically navigate applying population-level evidence to individual patient decisions, and what resources or frameworks do you find most helpful for staying current with the latest research while managing a full patient load?