12-24-2025, 05:58 AM
I'm a family physician trying to better understand the practical implications of direct-to-consumer genetic testing for my patients, as more of them are coming in with raw data from companies like 23andMe asking for interpretation. I'm comfortable with Mendelian inheritance but feel out of my depth when patients have questions about polygenic risk scores for complex conditions or what a specific SNP variant might actually mean for their health. For medical professionals who have integrated this into their practice, what resources or continuing education have you found most reliable for staying current? How do you counsel patients on the limitations and potential psychological impact of these results, especially when they indicate an elevated risk for diseases with no clear preventive action?