I always get confused between acetaminophen and ibuprofen. For a regular tension headache, is there a general rule for which one to try first? I know the acetaminophen dose on the bottle, but I'm never sure which medicine is better for what.
In general, start with acetaminophen first if you have no liver risk.
Acetaminophen and ibuprofen work differently. Acetaminophen dose should stay under about 4,000 mg per day to avoid liver damage; ibuprofen is an NSAID that can irritate the stomach and affect kidneys, so take it with food and use the lowest effective dose. citeturn0search3turn0search2
Here's a simple way to decide: if your headache is mostly tension plus you tolerate NSAIDs, ibuprofen can be stronger for that kind of pain; if you have stomach ulcers or kidney issues, acetaminophen is safer. Also check other meds for acetaminophen so you don't exceed the max daily dose. Start with the smallest dose and give it an hour or so to work; if it lingers after a day or two, check in with a clinician. citeturn0search6
Here is a practical plan you can actually follow. Start by counting any acetaminophen in meds you take so you don’t blow past the max daily dose. Typical OTC acetaminophen is 500–650 mg every 4–6 hours, max 3,000–4,000 mg daily; ibuprofen is 200–400 mg every 4–6 hours, max 1,200 mg OTC (higher with a prescription). Avoid alcohol with acetaminophen and don’t use NSAIDs if you have ulcers or kidney issues. If headaches persist, talk with a clinician for a tailored plan and consider non drug strategies like hydration and breaks. If you ever notice warning signs like confusion, severe weakness, or vision changes seek care right away.